Preheat oven to 400 degrees. Prepare all ingredients.
Heat 3 tablespoons extra virgin olive oil in a skillet. Sauté shrimp until they just turn pink. Add red pepper flakes. (You will likely need to split this shrimp into two batches given the quantity.) Transfer sauteed shrimp to a baking dish.
Heat 3 tablespoons extra virgin olive oil in the same skillet. Sauté chopped onions until cooked down, 3-4 minutes, then add chopped garlic and continue to sauté for another minute. Add the dry white wine, and cook for 2 minutes over high heat.
Stir in the chopped tomatoes, fresh chopped parsley, Greek oregano, salt and fresh ground pepper to taste. Simmer, uncovered, for 15 minutes.
Pour the tomato mixture evenly over the shrimp in the baking dish.
Sprinkle crumbled feta cheese evenly over the tomato sauce.
Transfer the baking dish to a 400° oven and bake for 15 minutes or until feta cheese has melted and slightly browned on top. Serve immediately over Penne pasta and some crusty bread.